Beilstein Arch. 2025, 202520. https://doi.org/10.3762/bxiv.2025.20.v1
Published 20 Mar 2025
A new synthetic route initiated with Groebke-Blackburn-Bienaymé (GBB) followed by N-acylation, intramolecular Diels-Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the sunstitution groups for the IMDA reaction is analyzed to understand the reaction mechanism.
Keywords: Groebke-Blackburn-Bienaymé (GBB), Intramolecular Diles-Alder (IMDA), Multicomponent reaction (MCR), Re-aromatization, Imidazopyridine, Isoquinolinone
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Nath, A.; Awad, J. M.; Zhang, W. Beilstein Arch. 2025, 202520. doi:10.3762/bxiv.2025.20.v1
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