Beilstein Arch. 2024, 202465. https://doi.org/10.3762/bxiv.2024.65.v1
Published 05 Nov 2024
The all-syn deoxypropionate motif can be efficiently constructed using a combination of enzymatic desymmetrization and substrate-controlled conjugate addition of lithium dimethylcopper. This strategy was used to prepare mycocerosic acid, from Mycobacterium tuberculosis, and the sex pheromone of Margarodes prieskaensis (Jakubski), both in 10% overall yield.
Keywords: Conjugate addition; deoxypropionates; enzymatic desymmetrisation; mycocerosic acid; pheromones.
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Le Calvez, G.; Witte, M. D.; Minnaard, A. J. Beilstein Arch. 2024, 202465. doi:10.3762/bxiv.2024.65.v1
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