Beilstein Arch. 2024, 202457. https://doi.org/10.3762/bxiv.2024.57.v1
Published 14 Aug 2024
C1 chemistry has a central role in efficiently utilizing single-carbon-molecules contributing significantly to sustainability, innovation and economic growth across various sectors. In this study, we present an efficient and rapid method for synthesizing a variety of heteropyrimidones using cyanoacetamide-based multicomponent reaction (MCR) chemistry. By employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolo-pyrimidones in a one-pot process. A single crystal structure has been obtained revealing certain geometrical features.
Keywords: Multicomponent reactions; cyanoacetamide; pyrimidone; Gewald; 2-amino heterocycles
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Zingiridis, M.; Papachristodoulou, D.; Menegaki, D.; Froudas, K. G.; Neochoritis, C. Beilstein Arch. 2024, 202457. doi:10.3762/bxiv.2024.57.v1
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