Beilstein Arch. 2024, 202440. https://doi.org/10.3762/bxiv.2024.40.v1
Published 12 Jun 2024
An efficient one-step procedure for the synthesis of a new series of multifunctional olefins by condensation of β-diketones as well as β-phosphonoesters and benzoylated β-ketoesters with formaldehyde, using potassium carbonate in refluxing THF, followed by a deacylation reaction, is herein described. In contrast, acetylated β-keto esters derivatives, only undergo a hydroxymethylation reaction, affording the corresponding α-hydroxymethyl β-keto esters in high yields.
Keywords: β-Dicarbonyl derivatives; Morita–Baylis–Hillman; Olefination; Wittig-Horner; Deacylation; Hydroxymethylation
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Mhasni, O.; Legros, J.; Rezgui, F. Beilstein Arch. 2024, 202440. doi:10.3762/bxiv.2024.40.v1
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