Liver-Targeting Nanoparticles of iron oxide (Fe3O4) and their complexes with phytopreparation for the biocompatibility

Shushanik A. Kazaryan; Seda A. Oganian; Gayane S. Vardanyan; Anatolie S. Sidorenko; Ashkhen A. Hovhannisyan

doi:10.3762/bxiv.2024.52.v1

Liver-Targeting Nanoparticles of iron oxide (Fe₃O₄) and their complexes with phytopreparation for the biocompatibility

Shushanik A. Kazaryan ,
Seda A. Oganian ,
Gayane S. Vardanyan ,
Anatolie S. Sidorenko and
Ashkhen A. Hovhannisyan

Submitting author affiliation:

Institute of Electronic Engineering and Nanotechnologies of TUM, Chisinau, Moldova

Beilstein Arch. 2024, 202452. https://doi.org/10.3762/bxiv.2024.52.v1

Published 29 Jul 2024

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SUBJECT AREAS

Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

Thanks to their simple synthesis, controlled physical properties, and minimal toxicity, iron oxide nanoparticles (Fe₃O₄ NPs) are widely used in many biomedical applications (bioimaging, drug delivery, biosensors, diagnostics, theranostics, etc.). However, the use of NPs does not preclude the possibility of some selective toxicity and undesirable effects, including their accumulation in tissues and direct interaction with specific biological targets. This study evaluated the biocompatibility of Fe₃O₄ NPs, Teucrium polium (T. polium) extract, rutin, and their complexes on the liver tissue of healthy white Wistar rats.The impact profile of the synthesized Fe₃O₄ NPs (15 ± 4 nm), rutin, T. polium extract, and their complexes on biochemical markers of liver function (ALT, AST, ALP, GGT, HDL, LDL, total cholesterol, total protein, albumin) and morphological indicators of rat liver was investigated. Fe₃O₄ NPs, rutin, and T. polium extract do not have direct hepatotoxicity when administered i/p to rats, unlike their complexes. All agents exert a hypolipidemic effect by lowering LDL, despite maintaining the synthetic functions of the liver. Fe₃O₄ NPs increase the activity of GPO, which is associated with their peroxidase-like properties. A multifaceted and diverse mechanism of action of all studied samples on the liver of Wistar rats was identified.

Keywords: iron oxide (Fe₃O₄) nanoparticle; T. polium; rutin; hepatotoxicity; biocompatibility

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kazaryan, S. A.; Oganian, S. A.; Vardanyan, G. S.; Sidorenko, A. S.; Hovhannisyan, A. A. Beilstein Arch. 2024, 202452. doi:10.3762/bxiv.2024.52.v1

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© 2024 Kazaryan et al.; licensee Beilstein-Institut.
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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
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benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)