and
Beilstein Arch. 2024, 202452. https://doi.org/10.3762/bxiv.2024.52.v1
Published 29 Jul 2024
Thanks to their simple synthesis, controlled physical properties, and minimal toxicity, iron oxide nanoparticles (Fe3O4 NPs) are widely used in many biomedical applications (bioimaging, drug delivery, biosensors, diagnostics, theranostics, etc.). However, the use of NPs does not preclude the possibility of some selective toxicity and undesirable effects, including their accumulation in tissues and direct interaction with specific biological targets. This study evaluated the biocompatibility of Fe3O4 NPs, Teucrium polium (T. polium) extract, rutin, and their complexes on the liver tissue of healthy white Wistar rats.The impact profile of the synthesized Fe3O4 NPs (15 ± 4 nm), rutin, T. polium extract, and their complexes on biochemical markers of liver function (ALT, AST, ALP, GGT, HDL, LDL, total cholesterol, total protein, albumin) and morphological indicators of rat liver was investigated. Fe3O4 NPs, rutin, and T. polium extract do not have direct hepatotoxicity when administered i/p to rats, unlike their complexes. All agents exert a hypolipidemic effect by lowering LDL, despite maintaining the synthetic functions of the liver. Fe3O4 NPs increase the activity of GPO, which is associated with their peroxidase-like properties. A multifaceted and diverse mechanism of action of all studied samples on the liver of Wistar rats was identified.
Keywords: iron oxide (Fe3O4) nanoparticle; T. polium; rutin; hepatotoxicity; biocompatibility
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Kazaryan, S. A.; Oganian, S. A.; Vardanyan, G. S.; Sidorenko, A. S.; Hovhannisyan, A. A. Beilstein Arch. 2024, 202452. doi:10.3762/bxiv.2024.52.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2024 Kazaryan et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
