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Beilstein Arch. 2024, 202448. https://doi.org/10.3762/bxiv.2024.48.v1
Published 11 Jul 2024
Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of this is often difficult. One promising solution may be the development of antidote delivery systems that will release the drug only when acetylcholine levels are elevated. This approach will ensure timely delivery of the antidote and minimize side effects associated with uncontrolled drug release. Here, we describe the creation of a new smart system that serves as a carrier for delivering an antidote (atropine) and functions as a synthetic esterase to hydrolyze acetylcholine. The nanocarrier was synthesized through microemulsion polycondensation of phenylboronic acid with resorcinarenes containing hydroxyl, imidazole, and carboxylic groups on the upper rim. The nanocarrier breaks down acetylcholine into choline and acetic acid. The last one acts on boronate bonds, dissociating them. It leads to the destruction of the nanocarrier and the release of the antidote. The paper covers the creation of the nanocarrier, its physicochemical and biological properties, encapsulation of the antidote, acetylcholine hydrolysis, and antidote release.
Keywords: Antidote delivery; atropine; nanocarrier; resorcinarene; acetylcholine, artificial cholinesterase
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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Mansurova, E. E.; Maslennikov, A. A.; Lyubina, A. P.; Voloshina, A. D.; Nizameev, I. R.; Kadirov, M. K.; Ziganshina, A. Y.; Antipin, I. S. Beilstein Arch. 2024, 202448. doi:10.3762/bxiv.2024.48.v1
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