Abstract

We propose the use of gold nanoparticles grown on the surface of nanoporous TiO₂ films as Surface Enhanced Raman Scattering (SERS) sensors for the detection of 17β-estradiol. Gold deposition on top of TiO₂ surfaces leads to the formation of nanoparticles, which plasmonic properties fit the requirements of a SERS sensor well. The morphological and optical properties of this surface were investigated. Specifically, we demonstrated that the TiO₂ background pressure during pulsed laser deposition and annealing conditions enabled the formation of a variety of Au nanoparticles with controlled size, shape and distribution thus resulting in a versatile sensor. We have exploited this surface for the detection of 17β-estradiol, an emerging contaminant in environmental waters. We have found a limit of detection of 10 nM with a sensitivity allowing dynamic range of five orders of magnitude (up to 100 µM).

Keywords: TiO₂ nanostructures, Au nanoparticles, plasmonics, SERS, estradiol, E2, sensor, aptamer

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Brognara, A.; Mohamad Ali Nasri, I. F.; Bricchi, B. R.; Li Bassi, A.; Gauchotte-Lindsay, C.; Ghidelli, M.; Lidgi-Guigui, N. Beilstein Arch. 2020, 202029. doi:10.3762/bxiv.2020.29.v1

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