Beilstein Arch. 2020, 202020. https://doi.org/10.3762/bxiv.2020.20.v1
Published 17 Feb 2020
A diastereo- and enantioselective approach to access chiral CF2-functionalized aziridines from phenylsulfone difluorodiazoethane (PhSO2CF2CHN2) and in-situ formed aldimines is described. This multicomponent reaction is enabled by a combined strong Brønsted acid catalytic platform consisting of a chiral disulfonimide and 2-carboxyphenylboronic acid. The optical purity of obtained CF2-aziridines could be further improved by a practical dissolution-filtration procedure.
Keywords: difluoromethyl compounds; aziridines; fluorinated diazo reagents; chiral disulfonimides; strong Brønsted acids
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Tan, X.-F.; Zhang, F.-G.; Ma, J.-A. Beilstein Arch. 2020, 202020. doi:10.3762/bxiv.2020.20.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2020 Tan et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)
