Beilstein Arch. 2019, 201910. https://doi.org/10.3762/bxiv.2019.10.v1
Published 17 Apr 2019
Asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 85% yield, which was converted into t-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 11 steps via a β-hydroxy ketone.
Keywords: cycloaddition; silyl nitronate; isoxazoline; β-hydroxy ketone; 1,3-diol
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Feng, J.; Li, T.; Zhang, J.; Jiao, P. Beilstein Arch. 2019, 201910. doi:10.3762/bxiv.2019.10.v1
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