Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

Tivadar Feczkó; Albrecht Piiper; Thomas Pleli; Christian Schmithals; Dominic Denk; Thomas J. Vogl; Matthias G. Wacker

doi:10.3762/bxiv.2019.1.v1

Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

Tivadar Feczkó ,
Albrecht Piiper ,
Thomas Pleli ,
Christian Schmithals ,
Dominic Denk ,
Thomas J. Vogl and
Matthias G. Wacker

Submitting author affiliation:

Hungarian Academy of Sciences Research Centre for Natural Sciences, Budapest, Hungary

Beilstein Arch. 2019, 20191. https://doi.org/10.3762/bxiv.2019.1.v1

Published 10 Apr 2019

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SUBJECT AREAS

Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

Background: Efficient delivery of the poorly water-soluble compound sorafenib still poses a challenge to current formulation strategies. To incorporate the lipophilic molecule into biocompatible and biodegradable theranostic nanoparticles has great potential for improving efficacy and safety of cancer therapy.

Results: In this study, sorafenib nanoencapsulation was optimized using poly(D,L-lactide-co-glycolide) and polyethylene glycol-poly(D,L-lactide-co-glycolide) copolymers comparing three different technologies. The particles ranged in size between 220 and 240 nm with encapsulation efficiencies from 76.1 ± 1.7 % to 69.1 ± 10.1 %. A remarkable maximum drug load of 9.0 % was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface transforming the nanospheres into theranostic devices allowing the localization using magnetic resonance imaging.

Conclusion: The manufacture of sorafenib-loaded nanoparticles and the functionalization of the particle surface with a gadolinium complex resulted in a high drug loading, a strong MRI signal, optimal stability features and a sustained release profile.

Keywords: gadolinium; drug release; polymeric nanocarrier; sorafenib; theranostic nanoparticles

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Feczkó, T.; Piiper, A.; Pleli, T.; Schmithals, C.; Denk, D.; Vogl, T. J.; Wacker, M. G. Beilstein Arch. 2019, 20191. doi:10.3762/bxiv.2019.1.v1

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© 2019 Feczkó et al.; licensee Beilstein-Institut.
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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)